| 氨苄青霉素三水酸水解工艺的研究 |
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| 引用本文： | 程志清.氨苄青霉素三水酸水解工艺的研究[J].昆明理工大学学报(理工版),2000,25(4):111-113. |
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| 作者姓名： | 程志清 |
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| 作者单位： | 丽珠医药集团股份有限公司,生产管理部,广东,珠海,519020 |
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| 摘 要： | 目的：获得氨苄青霉素三水酸水解反应需要控制的最佳pH值。方法：测定两种温度下不同pH值时的氨苄青霉素三水酸的溶解度，作为溶解度－pH值的关系曲线，并回归分析得到溶解度－pH值的回归方程，经计算推测出氨苄青霉素三水酸的溶解度最大时的pH值。结果：pH值为1．0时，氨苄青霉素三水酸的溶解度最大。结论：水解反应控制pH值为1．0时，水解反应完全，无结晶析出，收率高。
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| 关 键 词： | 氨苄青霉素三水酸 水解工艺 PH值 溶解度 |
| 修稿时间： | 2000-06-20 |
Study on Hydrolysis Process of Ampicillin Trihydrate |
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| CHENG Zhi-qing.Study on Hydrolysis Process of Ampicillin Trihydrate[J].Journal of Kunming University of Science and Technology(Natural Science Edition),2000,25(4):111-113. |
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| Authors: | CHENG Zhi-qing |
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| Abstract: | Objective: To obtain the best value of pH using the hydrolysis process of ampicillin trihydrate. Methods: assay solubility of ampicillin trihydrate at two temperatures with different pH. Draw the related curve between solubility and pH, obtained regression equation. Suspected the pH under the max. of solubility of ampicillin trihydrate by calculation. Results: when pH is 1.0, solubility of ampicillin trihydrate is at the maximum. Conclusion: when pH is 1.0, hydrolys is completely, no crystal of ampicillin trihydrate precipitated, the ratio obtained ampicillin trihydrate is high. |
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| Keywords: | ampicillin trihydrate hydrolysis process value of pH solubility |
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