提高结晶山梨醇熔点的工艺探讨

山梨醇是一种用途广泛的化工、食品、医药原料,结晶山梨醇应用更广,但必须掌握好其结晶的条件才能制备出熔点高的结晶山梨醇。本文对山梨醇结晶的工艺条件进行了深入研究,通过对结晶温度、结晶时间、晶种用量及晶种粒度进行了单因素对比试验,并用三因素三水平正交试验表安排了正交试验,优化结晶工艺条件。根据正交试验结果的极差分析及方差分析,对三因素的显著性作出了判断,确定了影响结晶山梨醇熔点的显著因素为结晶温度,也找出了原来产品熔点低的主要原因,对原装置上的结晶温度控制系统进行了改造,并对操作人员进行了培训,按优化的条件生产后,结晶山梨醇的熔点稳定达到101℃以上,达到进口样品的水平,其优化的条件为:结晶温度:70℃,结晶时间:40min,晶种用量:10%。

Technology for improving the melting point of crystal sorbitol

The sorbitol is widely used in chemical,foodstuff,medicine field.The crystal sorbitol is more widely used.But,the crystallization technological conditions must be well controlled for higher melting point of crystal sorbitol.The single factor experiment about the crystallization temperature,crystallization time,seed dosage and the seed size were studied.The orthogonal tests were carried out according to L9(34)and the crystallization technological conditions were optimized.The significant factor was determined and the analyzed.The significant factor was the crystallization temperature.The crystallization temperature in the old equipment was changed and the operating staffs was trained.The melting point of crystal sorbitol reached stably over 101℃ under the optimized conditions.The optimized conditions were:crystallization temperature:70℃,crystallization time:40min,crystallization seed dosage:10%.