Stabilization of a new antiulcer drug (Lansoprazole) in the solid dosage forms |
| |
| Authors: | Tetsuro Tabatar Tadashi Makino Toshio Kashihara Shinichiro Hirai Nobuyuki Kitamori Hajime Toguchi |
| |
| Affiliation: |
a Pharmaceutics Research Laboratories, Research & Development Division, Takeda Chemical Industries, Ltd., 17-85, Juso-honmachi 2-Chome Yodogawa-ku, Osaka, (Japan) |
| |
| Abstract: | In the previous study, we clarified that enteric granules were appropriate dosage forms of lansoprazole. The establishment of these formulations, however, was difficult because some of the excipients needed for these formulations are incompatible with the drug. We examined the effects of adding magnesium carbonate as an alkaline stabilizer and could get stable enteric granules. We also discuss the mechanism of stabilization. |
| |
| Keywords: | lansoprazole enteric granules magnesium carbonate mechanism of stabilization stabilizer |
| 本文献已被 InformaWorld 等数据库收录！ |
|
