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Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation |
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| Authors: | Tetsu Yamaguchi Shinji Sakai Rie Watanabe Takashi Tarao Koei Kawakami |
| Affiliation: | 1 Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, 1465-5 Aikawa, Kurume, Fukuoka 839-0861, Japan;2 Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan;3 Japan Vilene Company, Ltd., 7 Kita-Tone, Koga-shi, Ibaraki 306-0213, Japan |
| Abstract: | Synthetic scaffolds support cell attachment in vitro. We prepared ultra-fine silicate fibers using the sol–gel process and electrospinning, heated the fibers to 500 °C and investigated their effects on the behavior of human hepatocellular carcinoma (HepG2) cells. Alterations in surface composition following heat treatment improved cell adhesion and influenced cell migration. |
| Keywords: | Silicate Electrospinning Sol&ndash gel method 3D-Cell culture HepG2 |
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