Production of human growth hormone by Lactococcus lactis |
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| Authors: | Abelardo Margolles,José Antonio Moreno,Lorena Ruiz,Belkis Marelli,Christian Magni,Clara G. de los Reyes-Gavilá n,Patricia Ruas-Madiedo |
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| Affiliation: | 1 Departamento de Microbiología y Bioquímica de Productos Lácteos, Instituto de Productos Lácteos de Asturias (CSIC), Carretera de Infiesto s/n 3300 Villaviciosa, Asturias, Spain;2 Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET) and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531 (S2002LRK) Rosario, Argentina |
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| Abstract: | A synthetic gene coding for human growth hormone was expressed in Lactococcus lactis. The presence of the recombinant protein was assayed and quantified using ELISA tests. Human growth hormone was detected at high concentrations and displayed a biological activity similar to the one shown by commercial human growth hormone. |
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| Keywords: | Human growth hormone Heterologous expression Lactococcus lactis Food-grade Caco-2 proliferation |
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