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Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4 |
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| Authors: | Heribert Warzecha Daniela Ferme Markus Peer Andreas Frank Matthias Unger |
| Affiliation: | 1 Technische Universitaet Darmstadt, Department for Biology, Schnittspahnstr.3-5, 65287 Darmstadt, Germany;2 Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians Universität, 97074 Würzburg, Germany;3 Julius-von-Sachs-Institut, Julius-Maximilians Universität, 97082 Würzburg, Germany |
| Abstract: | In this study we have expanded the metabolic potential of plant cell suspension cultures by introducing active human cytochrome P450 monooxygenase 3A4 into tobacco cells. Exogenously supplied loratadine was metabolized in a 3A4-specific manner, showing the capacity of this system for the generation of metabolites. |
| Keywords: | Plant cell suspension cultures P450 3A4 Loratadine Biotransformation Plant metabolic engineering |
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