| 硼中子俘获治疗癌症的基础性实验研究 |
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| 引用本文： | 蔡明辉,赵葵,展永,郭继宇,倪嵋楠,隋丽,孔福全,杨明建.硼中子俘获治疗癌症的基础性实验研究[J].原子能科学技术,2006,40(4):391-395. |
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| 作者姓名： | 蔡明辉 赵葵 展永 郭继宇 倪嵋楠 隋丽 孔福全 杨明建 |
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| 作者单位： | 1.中国原子能科学研究院 ;核物理研究所， ;北京 ; 102413；2.河北工业大学 ;理学院， ;天津 ; 300130；3.北京师范大学 ;射线束技术与材料改性教育部重点实验室， ;北京 ; 100875 ; |
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| 基金项目： | 国家自然科学基金资助项目(10175095,10474018,10435020)，北京凯佰特科技有限公司资助项目 |
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| 摘 要： | 分别利用241Am放射源和HI-13串列加速器产生的α粒子和7Li离子来模拟硼中子俘获治疗中的核反应产物，对DNA水溶液进行辐照，然后利用原子力显微镜(AFM)对DNA碎片进行观测，最后通过大量的统计分析获取DNA碎片长度、DNA形态的实验数据。实验结果表明：DNA碎片的平均长度随剂量的增大逐渐减小；线性和开环的DNA分子所占的比例随着剂量的增大逐渐增多；7Li离子比α粒子具有更强的相对生物学效应。
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| 关 键 词： | 硼中子俘获治疗 癌症 质粒DNA 原子力显微镜 辐照 |
| 文章编号： | 1000-6931（2006）04-0391-05 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006-01-102006-02-23 |
Basic Experimental Study on Boron Neutron Capture Therapy |
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| CAI Ming-hui , ZHAO Kui , ZHAN Yong , GUO Ji-yu , NI Mei-nan , SUI Li, KONG Fu-quan , YANG Ming-jian.Basic Experimental Study on Boron Neutron Capture Therapy[J].Atomic Energy Science and Technology,2006,40(4):391-395. |
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| Authors: | CAI Ming-hui ZHAO Kui ZHAN Yong GUO Ji-yu NI Mei-nan SUI Li KONG Fu-quan YANG Ming-jian |
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| Affiliation: | 1.China Institute of Atomic Energy, P.O.Box 275-10, Beijing 102413, China; 2.School of Science, Hebei University of Technology, Tianjin 300130, China; 3.Key Laboratory of Beam Technology and Modification of Ministry of Education, Beijing Normal University, Beijing 100875, China ; |
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| Abstract: | α particles and 7 Li ions are produced by radionuclide 241Am and the HI-13 tandem accelerator respectively to simulate productions of BNCT(Boron Neutron Capture Therapy). DNA solution is irradiated by the above rays in air firstly, and then the DNA fragments are analized by AFM(Atomic Force Microscopy). The software ImageJ is used to measure the length of DNA fragments. Lastly, the experimental data of DNA fragments and DNA configuration are obtained. The results show that the mean length of DNA fragments increase as dose decreases; the fraction of linear and open circle DNA molecules increase as dose decreases; lithium particles cause strong relative biological effects than α particles. |
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| Keywords: | boron neutron capture therapy cancer plasmid DNA atomic force microscopy irradiation |
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