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Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Authors:Wan Zhao-Kui  Lee Jinbo  Hotchandani Rajeev  Moretto Alessandro  Binnun Eva  Wilson Douglas P  Kirincich Steve J  Follows Bruce C  Ipek Manus  Xu Weixin  Joseph-McCarthy Diane  Zhang Yan-Ling  Tam May  Erbe David V  Tobin James F  Li Wei  Tam Steve Y  Mansour Tarek S  Wu Junjun
Affiliation:Chemical and Screening Sciences, Wyeth Research, 200 Cambridgepark Drive, Cambridge, MA 02140, USA.
Abstract:
Keywords:diabetes  obesity  protein tyrosine phosphatase  structure–activity relationships  drug design
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