| 手性氨基醇用于苯乙酮的不对称还原研究 |
| |
| 引用本文： | 刘湘,李纪国,张正.手性氨基醇用于苯乙酮的不对称还原研究[J].食品与生物技术学报,1997,16(3). |
| |
| 作者姓名： | 刘湘 李纪国 张正 |
| |
| 作者单位： | 无锡轻工大学化学工程系，南京大学化学系 |
| |
| 摘 要： | 合成了（１Ｒ，２Ｓ）－１－二丁基氨基－１，２－二氢－２－茚醇及其对映体，首次将此类手性氨基醇用于苯乙酮的不对称还原反应研究，用温和的还原剂ＫＢＨ４，得到的还原产物１－苯基乙醇其最佳对映体过量值达８１％．同时还调查了反应时间对转化率和对映体过量值的影响，确定７０ｈ为最合适的反应时间。
|
| 关 键 词： | 不对称还原 手性氨基醇 苯乙酮 硼氢化钾 |
Study on the Asymmetric Reduction of Acetophenone in the Presence of Chiral Amino Alcohols |
| |
| Liu Xiang.Study on the Asymmetric Reduction of Acetophenone in the Presence of Chiral Amino Alcohols[J].Journal of Food Science and Biotechnology,1997,16(3). |
| |
| Authors: | Liu Xiang |
| |
| Abstract: | R,2S) 1 Dibutylamino 2 indanol and its enantiomer were synthesized. These chiral amino alcohols were first applied to the asymmetric reduction of acetophenone. Using mild reductant KBH 4, optically active 1 phenylethanol was obtained with enantiomeric excesses up to 81%. The effect of reaction time on conversion and enantiomeric excesses was also investigated and 70 hours was found to be the most suitable reaction time. |
| |
| Keywords: | asymmetric reduction chiral amino alcohol acetophenone potassium borohydride |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《食品与生物技术学报》浏览原始摘要信息 |
|
点击此处可从《食品与生物技术学报》下载全文 |
