| 糖尿病性肌少症发病机制和治疗靶点的研究进展 |
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| 引用本文： | 丁 凡,李文雄,张佳莉,张 岩.糖尿病性肌少症发病机制和治疗靶点的研究进展[J].金属学报,2019,24(12):1428-1433. |
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| 作者姓名： | 丁 凡 李文雄 张佳莉 张 岩 |
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| 作者单位： | 1.上海中医药大学附属龙华医院；;2.教育部筋骨理论与治法重点实验室，上海 200032 |
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| 基金项目： | 国家自然科学基金资助项目（81774329）；上海市市级医疗卫生优秀学科带头人培养计划资助（2018BR03）；上海市优秀学术带头人计划资助（19XD1423800）；科技部重大新药创制资助（2019ZX09201004-003-032）；教育部创新团队（IRT1270）；上海市自然科学基金（17ZR1430800） |
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| 摘 要： | 糖尿病是一种以高血糖为特征的代谢性疾病，肌少症是其常见的慢性并发症之一。糖尿病性肌少症可能与泛素-蛋白酶体系统、胰岛素抵抗、氧化应激、线粒体损伤、胰岛素信号通路、晚期糖基化终末产物有关。本文根据国内外文献，对糖尿病性肌少症的发病机制和治疗靶点进行综述。
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| 关 键 词： | 糖尿病 肌少症 泛素-蛋白酶体系统 胰岛素抵抗 氧化应激 |
| 收稿时间： | 2019-11-05 |
| 修稿时间： | 2019-05-05 |
Research progress on pathology mechanism and treatment target for diabetic sarcopenia |
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| DING Fan,LI Wenxiong,ZHANG Jiali,ZHANG Yan.Research progress on pathology mechanism and treatment target for diabetic sarcopenia[J].Acta Metallurgica Sinica,2019,24(12):1428-1433. |
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| Authors: | DING Fan LI Wenxiong ZHANG Jiali ZHANG Yan |
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| Affiliation: | 1. Longhua Hospital,Shanghai University of Traditional Chinese Medicine;2.Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai 200032, China |
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| Abstract: | Diabetes is a kind of metabolic diseases characterized by hyperglycemia. Sarcopenia is one of the common diabetic complications. Development of diabetic sarcopenia is related to ubiquitin-proteasome system,insulin resistance,oxidative stress,mitochondria damage,insulin signaling pathway and advanced glycationend products.This review summarized the pathological mechanism and treatment targets for diabetic sarcopenia based on national and international literatures. |
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| Keywords: | diabetes sarcopenia ubiquitin-proteasome system insulin resistance oxidative stress |
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