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新辅助化疗对胃癌手术患者罗库溴铵药效学影响
引用本文:连燕虹,姜慧芳,袁晓红,周惠丹,解康杰,方 军,金孝岠.新辅助化疗对胃癌手术患者罗库溴铵药效学影响[J].金属学报,2019,24(10):1161-1164.
作者姓名:连燕虹  姜慧芳  袁晓红  周惠丹  解康杰  方 军  金孝岠
作者单位:1.中国科学院肿瘤与基础医学研究所,中国科学院大学附属肿瘤医院,浙江省肿瘤医院麻醉科,杭州 310022,浙江;;2.皖南医学院附属弋矶山医院麻醉科,芜湖 241001,安徽
基金项目:浙江省医药卫生科技项目(2017KY027);浙江省自然科学基金(LQI5H020001)
摘    要:目的:观察新辅助化疗对胃癌手术患者罗库溴铵药效学影响。方法:50例择期行开放胃癌根治术患者,ASA分级Ⅰ或Ⅱ,性别不限,年龄40~68岁,体质量56~79 kg,25例术前未做化疗(N组),25例术前行新辅助化疗(C组)。静脉诱导患者入睡后,给予罗库溴铵0.9 mg/kg,当4次成串刺激(TOF)为0时插入气管导管,T1恢复至对照值25%时追加罗库溴铵0.15 mg/kg。记录罗库溴铵起效时间(给药至T1为0时间,t1)、首剂作用时间(首次给药至T1达25%时间,t2)、临床肌松时间(T1从0恢复至25%时间,t3)、恢复指数(T1从25%恢复至75%所需时间,RI)和拔管时间(停用肌松药至T4/T1恢复至90%时间,t4)和罗库溴铵的总用量。结果:与N组相比,C组肌松药首次作用时间延长,临床肌松时间延长,术中总用量减少,恢复指数和拔管时间延长(P<0.05)。两组患者起效时间无统计学差异(P>0.05)。结论:新辅助化疗可减少术中肌松药的使用量。

关 键 词:化疗    罗库溴铵    药效动力学    胃癌  
收稿时间:2019-07-15
修稿时间:2019-09-18

Effects of neoadjuvant chemotherapy on the pharmacodynamics of rocuronium bromide in patients undergoing gastric cancer surgery
LIAN Yanhong,JIANG Huifang,YUAN Xiaohong,ZHOU Huidan,XIE Kangjie,FANG Jun,JIN Xiaoju.Effects of neoadjuvant chemotherapy on the pharmacodynamics of rocuronium bromide in patients undergoing gastric cancer surgery[J].Acta Metallurgica Sinica,2019,24(10):1161-1164.
Authors:LIAN Yanhong  JIANG Huifang  YUAN Xiaohong  ZHOU Huidan  XIE Kangjie  FANG Jun  JIN Xiaoju
Affiliation:1.Department of Anesthesiology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, China;2. Department of Anesthesiology, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China
Abstract:AIM: To evaluate the effect of neoadjuvant chemotherapy on neuromuscular block induced by rocuronium in the patients undergoing radical gastrectomy. METHODS:Fifty patients with open gastric cancer, ASA Ⅰ or Ⅱ, aged 40 to 68 years old, 56-79 kg, scheduled for elective radical gastrectomy, were divided into 2 groups (n=25 each) according to whether the patient received neoadjuvant chemotherapy before operation or not: non-chemotherapy group (group N) and neoadjuvent chemotherapy group (group C). Anesthesia was induced with rocuronium 0.9 mg/kg injected intravenous. When T1 recovered to 25% of control height, IV infusion of rocuronium 0.15 mg/kg was used. The onset time, time for T1 to recover to 25%, recovery index and time for train of four ratios to recover to 90%, and the total amount of rocuronium were recorded. RESULTS:Compared with the group N, time for T1 to recover to 25%, recovery index and time for train of four ratios to recover to 90% were significantly prolonged, and the consumption of rocuronium was decreased in group C. There was no significant difference of onset time between the two groups. CONCLUSION:Neoadjuvant chemotherapy can reduce the usage of muscle relaxant in the patients undergoing radical gastrectomy.
Keywords:chemotherapy  rocuronium bomide  pharmacodynamics  gastric cancer  
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