血清降钙素原在细菌性脑膜炎中的价值

细菌性脑膜炎（BM）是儿童常见的中枢神经系统（CNS）疾病，对患儿健康具有严重威胁，及时对脑炎类型作出诊断并迅速启动治疗至关重要。目前诊断BM的金标准仍为脑脊液检查，但患儿配合度低，提取脑脊液操作难度和损失较大，且脑脊液培养耗时长、检测阳性率低，所以脑脊液检查对BM早期治疗的指导意义有限，存在延误病情的可能。血清降钙素原(S-PCT)对细菌感染早期预测有较高的敏感度和特异度。大量的证据表明S-PCT是评估已知或疑似CNS感染患者的有用工具，可以帮助诊断BM并评估预后。本文对目前关于S-PCT及其对BM的诊断和评估预后的价值等知识进行简要综述。

The value of serum calcitonin in bacterial meningitis

Bacterial meningitis (BM) is a common central nervous system disease (CNS) in children, which poses a serious threat to the health of children.Therefore, it is of great importance to timely diagnose the type of encephalitis and promptly start treatment.At present, the gold standard for the diagnosis of BM is still cerebrospinal fluid examination, but the cooperation degree of children is low, the extraction of cerebrospinal fluid is difficult and the loss is large, and the cerebrospinal fluid culture takes a long time and the positive detection rate is low, so the significance of cerebrospinal fluid examination for the early treatment of BM is limited, and there is the possibility of delay of the disease.Serum procalcitonin (S-PCT) has high sensitivity and specificity to early prediction of bacterial infection.A large amount of evidence indicates that S-PCT is a useful tool for evaluating patients with known or suspected CNS infection, which can help diagnose BM and evaluate prognosis.This paper reviewes the current knowledge about S-PCT and its value in diagnosis and prognosis evaluation of BM.