首页 | 本学科首页   官方微博 | 高级检索  
     

序贯法测定羟考酮皮下注射用于Stanford A型主动脉夹层撕裂患者术前镇痛的半数有效剂量
引用本文:周俊辉,孟宪慧.序贯法测定羟考酮皮下注射用于Stanford A型主动脉夹层撕裂患者术前镇痛的半数有效剂量[J].金属学报,2019,24(8):916-921.
作者姓名:周俊辉  孟宪慧
作者单位:河南省胸科医院手术麻醉科,郑州 450008,河南
基金项目:河南省医学科技攻关计划项目(201602299);河南省医学科技攻关计划(联合共建项目,2018020564)
摘    要:目的:采用序贯法测定羟考酮皮下注射用于Stanford A型主动脉夹层撕裂患者术前镇痛的半数有效剂量(ED50)。方法:Stanford A型主动脉夹层撕裂患者30例,美国麻醉医师协会(ASA)分级Ⅱ~Ⅲ级,拟于全身麻醉下行急诊手术。根据序贯法增减给药,麻醉前60 min时第一例患者皮下注射羟考酮5.0 mg,相邻剂量梯度为0.5 mg,若上一例患者镇痛效果满意,则下一例患者剂量减少0.5 mg;若上一例患者镇痛效果不满意,则下一例患者剂量增加0.5 mg。序贯给药后采用视觉模拟评分法(VAS)评估镇痛效果,VAS≤3分为镇痛有效。采用Dixon and Massey序贯分配试验法公式计算羟考酮皮下注射用于Stanford A型主动脉夹层撕裂患者术前镇痛中的ED50和95%可信区间。结果:镇痛效果满意组患者总体满意度高于镇痛效果不满意组(P<0.05),而两组补救镇痛率差异无统计学意义(P>0.05)。皮下注射羟考酮用于Stanford A型主动脉夹层撕裂患者术前镇痛的ED50为2.9 mg,95%可信区间为2.3~3.4 mg。结论:采用序贯法测得的皮下注射羟考酮用于Stanford A型主动脉夹层撕裂患者术前镇痛的ED50为2.9 mg,且此法简便、高效、准确性高。

关 键 词:羟考酮    皮下注射    主动脉夹层    术前用药    序贯法    半数有效剂量  
收稿时间:2018-12-10
修稿时间:2019-04-18

Sequential method for the determination of 50% effective dose of oxycodone for subcutaneous injection in preoperative analgesia in patients with Stanford type A aortic dissection
ZHOU Junhui,MENG Xianhui.Sequential method for the determination of 50% effective dose of oxycodone for subcutaneous injection in preoperative analgesia in patients with Stanford type A aortic dissection[J].Acta Metallurgica Sinica,2019,24(8):916-921.
Authors:ZHOU Junhui  MENG Xianhui
Affiliation:Department of Anesthesiology, Henan Provincial Chest Hospital, Zhengzhou 450008, Henan, China
Abstract:AIM: To determine the half effective dose (ED50) of oxycodone subcutaneously for preoperative analgesia in patients with Stanford type A aortic dissection using sequential method. METHODS: Thirty patients with Stanford type A aortic dissection were enrolled. The American Society of Anesthesiologists (ASA) grades II to III were scheduled for emergency surgery under general anesthesia. According to the sequential method of increasing or decreasing administration, the first patient was injected subcutaneously with oxycodone 5.0 mg 60 minutes before anesthesia, and the adjacent dose gradient was 0.5 mg. If the previous patient had satisfactory analgesic effect, the next patient dose was reduced by 0.5 mg. If the last patient's analgesic effect is not satisfactory, the next patient dose is increased by 0.5 mg. After sequential administration, visual analgesia (VAS) was used to evaluate the analgesic effect. VAS≤3 was effective in analgesia. The ED50 and 95% confidence intervals for preoperative analgesia in patients with Stanford type A aortic dissection were calculated using the Dixon and Massey sequential distribution test formula. RESULTS:The overall satisfaction of patients in satisfactory analgesic effect group was higher than that of patients in unsatisfactory analgesic effect group (P<0.05), but there was no significant difference between in the rate of remedy analgesia the two groups (P>0.05). The ED50 of subcutaneous oxycodone for preoperative analgesia in patients with Stanford type A aortic dissection was 2.9 mg with a 95% confidence interval of 2.3 to 3.4 mg. CONCLUSION:The ED50 of subcutaneous oxycodone for sequential analgesia in patients with Stanford type A aortic dissection was 2.9 mg, and the method was simple, efficient and accurate.
Keywords:oxycodone  subcutaneous injection  aortic dissection  preoperative medication  sequential method  half effective dose  
点击此处可从《金属学报》浏览原始摘要信息
点击此处可从《金属学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号