Liver and serum lipids and lipoproteins of rats fed 5% L-lysine |
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Authors: | P Hevia W J Visek |
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Affiliation: | (1) Schools of Basic Medical Sciences and Clinical Medicine, University of Illinois, 61801 Urbana, Illinois |
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Abstract: | Soybean protein and casein supplemented with 1% Arg were compared for their ability to prevent fatty livers caused by excess
dietary Lys. The concentrations of serum lipids and lipoproteins of rats fed 5% Lys and having vatty livers were also compared
with those of rats fed the identical diet but lacking fatty livers when killed. The total liver lipids, triglycerides and
cholesterol of rats fed 15% casein +5% Lys were 3.9, 12.4 and 2 times control values, respectively. Rats fed 5% Lys +1% Arg
or 5% Lys with 15% soybean protein had liver lipid concentrations similar to controls fed no supplemental Lys. Serum total
lipids, triglycerides, cholesterol, phospholipids and free fatty acids also did not change, and serum ketone bodies were slightly
elevated with Lys feeding whether the rats had fatty livers or not. The concentrations of circulating HDL were slightly depressed
in all rats fed 5% Lys while LDL were significantly elevated, particularly in rats without fatty livers. Serum VLDL did not
change with 5% dietary Lys. Overall, excessive dietary Lys caused fatty livers which were prevented by varying the diet or
length of feeding. Excess Lys feeding altered lipoprotein metabolism shown by decreased serum HDL and a substantial elevation
in LDL. The latter was more apparent when the fat accumulation in liver was less severe or absent. The data suggest that the
fatty liver from Lys excess is probably unrelated to increased fat mobilization from storage, decreased fat oxidation or to
a major block in the transport of triglycerides from the liver to the circulation. |
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