The effect of tricalcium silicate incorporation on bioactivity,injectability, and mechanical properties of calcium sulfate/bioactive glass bone cement |
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| Affiliation: | 1. Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, Iran;2. Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Azadi Sq., Mashhad, Iran;1. Department of Electronic Engineering, Huainan Union University, Huainan, PR China;2. Energy Storage Joint Research Center, School of Energy and Environment, Southeast University, No. 2 Si Pai Lou, Nanjing, 210096, PR China;3. Key Laboratory of Ferro and Piezoelectric Materials and Devices of Hubei Province, Faculty of Physics and Electronic Science, Hubei University, Wuhan, Hubei, 430062, PR China;4. Shenzhen Key Laboratory of Laser Engineering, Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, PR China;5. School of Electronic Engineering, Nanjing Xiaozhuang University, Nanjing, 211171, PR China;6. Institute of Physics, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan;1. Key Lab. for New Type of Functional Materials in Hebei Province, School of Materials Science and Engineering, State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Hebei University of Technology, 300132, Tianjin, China;2. AECC Sichuan Gas Turbine Establishment, Sichuan Province, Chengdu, 610500, China;1. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia;2. Nanomaterials and Nanotechnology Department, Advanced Materials Institute, Central Metallurgical R&D Institute (CMRDI), P.O. Box 87 Helwan, 11421, Cairo, Egypt;1. School of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China;2. Institute of Additive Manufacturing (3D Printing), Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China;3. School of Physics, Nanjing University of Aeronautics and Astronautics, Nanjing, 210000, China;4. School of Mechanical Engineering, Southeast University, Nanjing, 211189, China;5. Prismlab China Ltd., 200000, Shanghai, China;1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China;2. National Key Laboratory of Science and Technology on Materials under Shock and Impact, Beijing, 100081, China;3. Beijing Institute of Technology Chongqing Innovation Center, Chongqing, 401120, China |
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| Abstract: | The conventional Polymethyl methacrylate (PMMA) bone cement is not biodegradable and not bioactive to bond with the native bone and causes tissue necrosis resulting from its high exothermic polymerization. Hence, biodegradable bioactive bone cements with suitable setting time and mechanical properties should be introduced. In this study, novel bioactive bone cements containing Calcium Sulfate Hemihydrate (CSH), Bioactive Glass (BG), and Tricalcium Silicate (TSC) were developed. Firstly, CSH and BG binary system was optimized based on preliminary setting and mechanical tests. Secondly, the composite bioactive bone cements were obtained by adding different quantities of TCS to the optimized CS-BG (1.3:1 wt % ratio) system. All groups exhibited desirable handling properties, an initial setting time of lower than 15 min, injectability of greater than 85%, and controlled degradability. Moreover, they demonstrated initial compressive strength values of higher than 12 MPa, superior to trabecular bone. After 28 days of hydration, the compressive strength of the cement containing 30% TCS reached 51.04 MPa. Furthermore, the present bone cements showed favorable bioactivity and bone-bonding ability as a result of calcium carbonate and hydroxyapatite (HA) formation. Furthermore, this novel bone cement exhibited appropriate biocompatibility and mesenchymal stem cell attachment, suggesting its potential for clinical applications. |
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| Keywords: | Biomaterials Bone cement Bioactive Injectable Controllable degradation Improved compressive strength |
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