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Recent trends in bone defect repair and bone tissue regeneration of the two-dimensional material MXene
Affiliation:1. Research Center of Solid Oxide Fuel Cell, China University of Mining and Technology-Beijing, Beijing, 100083, China;2. Department of Energy Sciences, Faculty of Engineering, Lund University, P.O. Box 118, SE-221 00, Lund, Sweden;3. School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland, UK;1. National Innovation Institute of Additive Manufacturing, Xi''an, 710300, China;2. Center for Alloy Innovation and Design, State Key Laboratory for Mechanical Behavior of Materials, Xi''an Jiaotong University, Xi''an, 710049, China;3. School of Science, Xi''an University of Posts and Telecommunications, Xi''an, 710121, China;4. State Key Laboratory for Manufacturing Systems Engineering, Xi''an Jiaotong University, Xi''an, 710049, China;1. School of Mechanical and Energy Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023, China;2. Institute of Optoelectronic Materials and Devices, China Jiliang University, Hangzhou, 310018, China;3. Zhejiang Academy of Special Equipment Science, Hangzhou, 314415, China;1. School of Material Science and Engineering, Shandong University of Technology, Zibo, 255049, PR China;2. Beijing Special Engineering and Design Institute, Beijing, 100036, PR China;1. Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials, Maanshan, 243002, China;2. State Key Laboratory of Metal Material for Marine Equipment and Application, 114021, Anshan, China
Abstract:Bone defects have attracted much attention for a long time and seriously affect the function of the motor system. At present, the application of biological materials and biological scaffolds implanted in the defect site to promote the healing of bone defects is the main treatment method for bone defect repair. In recent years, the emergence of two-dimensional materials has brought new opportunities for biological materials. As a two-dimensional nanomaterial based on ceramics, MXene has unique physical and chemical properties, such as electrical conductivity, hydrophilicity, and antibacterial and photothermal effects, which make it a very broad application prospect in bone defect biomaterials. This review will start from the pathophysiological changes of bone defects and intervention factors of bone defect repair, introduce in detail the preparation and modification methods, physical and chemical properties and biological characteristics of the two-dimensional material MXene, and review the application status and research progress of MXene in bone defect repair and bone tissue regeneration. This provides a reference for the further application of MXene in bone defect repair.
Keywords:Bone defect repair  Bone tissue regeneration  MXene  Two-dimensional material
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