Development of antibacterial and morphological features of scaffolds based on polycaprolactone encapsulated with copper oxide/vanadium oxide for wound dressing applications |
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| Affiliation: | 1. Physics Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia;2. Physics Department, Faculty of Science, Zagazig University, Egypt;1. School of Materials Science and Engineering, Shanghai University, Shanghai, China;2. National Key Laboratory of Science and Technology on Underwater Acoustic Antagonizing, Shanghai, 201108, China;3. Shanghai Marine Electronic Equipment Research Institute, Shanghai, 201108, China;1. Institute of Surface/Interface Science and Technology, Key Laboratory of Superlight Material and Surface Technology of Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, China;2. Aviation Key Laboratory of Science and Technology on Advanced Corrosion and Protection for Aviation Material Beijing, Beijing Institute of Aeronautical Materials, Beijing, 100095, China;1. Henan Key Laboratory of High Temperature Functional Ceramics, School of Material Science and Engineering, Zhengzhou University, Zhengzhou, 450052, China;2. School of Material Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China;1. School of Industrial Metallurgical Engineering of Volta Redonda, Fluminense Federal University, Volta Redonda, RJ, 27276-210, Brazil;2. Institute of Mechanical Engineering, UNIFEI-Federal University of Itajubá, Itajubá, MG, 37500-903, Brazil;3. Department of Manufacturing and Materials Engineering, School of Mechanical Engineering, University of Campinas, Campinas, SP, 13083-860, Brazil;4. Faculty of Technology, Rio de Janeiro State University, Resende, RJ, 27537-000, Brazil;5. Center for Information Technology Renato Archer, Campinas, SP, 13069-901, Brazil;1. Department of Physics, Zhejiang Normal University, Jinhua, 321004, China;2. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China;3. College of Environment, Hohai University, Nanjing, 210098, China |
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| Abstract: | The development of highly effective dressing materials for human injuries that meet the complex requirements for clinical examination is still a challenge. In this regard, different biomaterials could be examined for wound dressing targets. Among these materials, polycaprolactone (PCL) is high biocompatible polymeric substance and has been used for numerous pharmaceutical applications. Furthermore, targeting antibacterial behavior could be done by merging additional nanoparticles such as copper oxide (CuO) and vanadium Oxide (V2O5). The scaffolds could be fabricated using the cast method, which is one of the most simple and facile methods. The morphological features and the surface roughness of the fabricated could be examined using X-ray diffraction, Raman spectroscopy, Fourier transform infrared (FTIR), and scanning electron microscopy (SEM) tests. The contact angle plays a significant role in studying the wettability of the scaffolds and the hydrophilic or hydrophobic behavior of the composed films. Besides the antibacterial behavior to evaluate the effectiveness of these scaffolds to protect the injury until the healing. The cell viability against human normal cells to examine the biocompatibility of the proposed compositions. In this regard, the topographical images show a smooth surface with random pores that have diameters in the range of 0.5–1.5 μm for pure PCL while, the porosity decreased with the addition of ginger and V2O5. The blend of CuO/V2O5/ginger@ PCL represents a noticeable increase in porosity with a diameter between 0.5 and 3 μm. The contact angles were recorded respectively at 55.02°, 54.12°, 53.89°, and 53.71° which refer to the tendency of the scaffolds to the hydrophilic behavior. In addition, the anti-bacterial activity of CuO/V2O5/ginger@PCL was represented with the diameter of the inhibition zone equal to 17.6±1.2 mm for E. coli and 12.3±1.2 mm for S. aureus. |
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| Keywords: | Wound dressing Polycaprolactone Wound bandages CuO Ginger |
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