The effect of chemical composition and morphology on the drug delivery properties of hydroxyapatite-based biomaterials |
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| Affiliation: | 1. Department of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Babe?-Bolyai University, 11 Arany János Street, RO-400028, Cluj-Napoca, Romania;2. Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babe?-Bolyai University, 11 Arany János Street, RO-400028, Cluj-Napoca, Romania;3. INCDO-INOE 2000, Research Institute for Analytical Instrumentation, 67 Donath Street, RO-400293, Cluj-Napoca, Romania;4. Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babe?-Bolyai University, 1 Mihail Kog?lniceanu Street, RO-400084, Cluj-Napoca, Romania;5. National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, RO-400293, Cluj-Napoca, Romania;6. Department of Chemistry and Chemical Engineering of Hungarian Line of Study, Faculty of Chemistry and Chemical Engineering, Babe?-Bolyai University, 11 Arany János Street, RO-400028, Cluj-Napoca, Romania;1. Institute of Aeronautics and Space, São José dos Campos, SP, 12228-904, Brazil;2. Institute for Advanced Studies, São José dos Campos, SP, 12228-001, Brazil;1. Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia;2. Department of Physics, College of Science, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia;1. Solid State Physics Department, Physics Research Institute, National Research Centre (NRC), Dokki, Giza, Egypt;2. Electric and Dielectric Materials Measurement Unit, National Research Centre (NRC), Dokki, Giza, Egypt;3. Spectroscopy Department, Physics Research Institute, National Research Centre (NRC), Dokki, Giza, Egypt;4. Nonlinear Optical Properties and Fluorescence Spectroscopy Unit, Physics Research Institute, National Research Centre (NRC), Giza, Egypt;5. Physics Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt;1. Departamento de Química, ICEx, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil;2. Faculdade de Física, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil;3. Departamento de Física, ICEx, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil;1. School of Metallurgy and Environment, Central South University, Changsha, 410083, China;2. National Center for International Research of Clean Metallurgy, Central South University, Changsha, 410083, China;3. Guangdong Guangqing Metal Technology Co. Ltd., Yangjiang, Guangdong, 529500, China |
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| Abstract: | In the case of orthopedic and dental interventions, local antibiotic therapy reduces significantly the risk associated with the intervention. The aim of this study was the preparation and characterization of pure hydroxyapatite (HA), Si- and Mg-doped HA, which ensures the sustained release of doxycycline, and the investigation of the parameters, which were crucial for the drug release. The carriers were synthesized using the precipitation method. In order to achieve different morphologies, traditional drying and spray drying methods were used: Si-doped HA was prepared using two different sources of Si, Na2SiO3 and Ludox AS-40, while (Mg(NO3)2)*6H2O was used for substitution with Mg. The carriers were characterized by XRD, SEM, EDX and TG/DTA methods, and the ion incorporation was also confirmed by lattice parameters calculations. Doxy was bound on the carriers by physical adsorption, the adsorption capacity increased proportionally by increasing the concentration of the initial Doxy solutions (10, 15, 20, 25 g/L). The investigated systems showed different releases with the change of the dissolution medium (in the case of HA microspheres, the release in PBS was twice as high as in SBF), chemical composition and morphology of the carriers. The retard effect of the carriers was improved by the spherical morphology, and the reduced release by ion substitution in both SBF and PBS increased as follows: HA < HASi1<HAMg < HASi2. The release mechanism of Doxy was discussed through five different release kinetics models. |
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| Keywords: | Hydroxyapatite Microspheres Spray drying Doxycycline Drug release |
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