Physicochemical and biological properties of composite bone cement based on octacalcium phosphate and tricalcium silicate |
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| Affiliation: | 1. College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China;2. Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China;3. Nanjing Haoqi Advanced Materials Co., Ltd., Nanjing, 211300, China;1. School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, People''s Republic of China;2. College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, People''s Republic of China;3. The Key Lab of Industrial Textile Material and Manufacturing Technology, Zhejiang Province, Hangzhou, 310018, People''s Republic of China;4. Zhejiang Jinda New Materials Co., Ltd., Zhejiang Province, Haining, 314419, People''s Republic of China;1. Spectroscopy Department, Physics Research Institute, National Research Center, 12311, 33 Elbehouth st., Dokki, Cairo, Egypt;2. Department of Physics, Faculty of Science, Mansura University, Mansoura, 35516, Egypt;1. Department of Physics and Electronic Science, Hunan University of Science and Technology, Xiangtan, 411201, China;2. School of Computer and Information Engineering, Hunan University of Technology and Business, Changsha, 410205, China;1. School of Materials Science and Engineering, Shandong University of Technology, Zibo, 255049, PR China;2. Shandong Baichuan Intelligent Technolgy Co., Ltd, Jinan, 250022, PR China;3. Shandong Yasai Ceramic Technolgy Co., Ltd, Jinan, 271100, PR China;1. School of Materials Science and Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, PR China;2. Laboratory for High Performance Transparent Protective Materials of Jiangsu Province, Jiangsu Tiemao Glass Co., Ltd., Nantong, 226600, PR China |
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| Abstract: | Biocompatible tricalcium silicate (C3S) bone cement is widely used as dental and bone repair material; however, its long setting time, poor injectability and low initial mechanical properties limit clinical applications. In order to improve C3S silicate bone cement and its derivatives to play a more important role in tooth restoration, bone defect repair, implant coating and tissue engineering scaffolds, a novel C3S and octacalcium phosphate (OCP) composite bone cement (OCP/C3S) was prepared and evaluated for setting time, injectability, anti-flocculation, pH, microstructure, bioactivity and cytotoxicity. The setting time of the OCP/C3S composite bone cement was controlled within the clinically operable time range (8.3–13.7 min); the cement exhibited good compressive strength, injectability (93.54%), and anti-collapse performance. The 20% OCP/C3S composite bone cement had a compressive strength of 28.94 MPa, 93% stronger than pure C3S (14.98 MPa). An in vitro immersion test showed that the composite bone cement had excellent hydroxyapatite forming ability, proper degradation rate, and a low pH value. Cellular experiments confirmed the low cytotoxicity of the composite bone cement and its great capacity for cell proliferation. These results indicate that 20% OCP/C3S composite bone cement is a promising biomaterial. |
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| Keywords: | Biomaterials Bone cement Properties Biocompatibility |
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