The effects of BaTiO3 on the handleability and mechanical strength of the prepared piezoelectric calcium phosphate silicate for bone tissue engineering |
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| Affiliation: | 1. College of Medicine and Biological Information Engineering, Northeastern University, 195 Chuangxin Road, Shenyang, 110169, China;2. School of Electrical Engineering, Shenyang University of Technology, 111 Shenliao West Road, Shenyang, 110870, China;3. Department of Orthopedics, General Hospital Northern Theater Command, 83 Wenhua Road, Shenyang, 110016, China;4. Department of Pediatric Dentistry, School of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang, 110002, China;5. Liaoning Provincial Key Laboratory of Oral Diseases, 117 Nanjing North Street, Shenyang, 110002, China;1. Faculty of Chemistry, University of Warsaw, Pasteur Street 1, 02-093, Warsaw, Poland;2. Department of the Theory of Continuous Media, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B Street, 02-106, Warsaw, Poland;3. Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 Str, 03-195, Warsaw, Poland;1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China;2. National Key Laboratory of Science and Technology on Materials under Shock and Impact, Beijing, 100081, China;3. School of Materials and Physics, China University of Mining and Technology, Xuzhou, 221116, China;4. School of Mechanical Engineering, Dongguan University of Technology, Dongguan, 523808, China;1. School of Material Science and Engineering, Shandong University of Technology, Zibo, 255049, PR China;2. Beijing Special Engineering and Design Institute, Beijing, 100036, PR China |
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| Abstract: | Natural bone is a piezoelectric material that can generate electrical signals when subjected to an external force. Although many studies have attempted to develop piezoelectric biomaterials for bone regeneration, post-treatment steps, such as sintering, are always needed. In this study, we prepared an injectable and piezoelectric bone substitute based on nanosized BaTiO3 (nBT)-added calcium phosphate silicate (CPS). The impacts of nBT on the CPS handleability and mechanical strength were characterized, and show that adding nBT could improve the CPS handleability but affect the CPS mechanical strength in a concentration-dependent manner (from 25.3 ± 1.0 MPa for 10BC to 13.5 ± 1.0 MPa for 40BC). In addition, our approach could fabricate a piezoelectric bone substitute with comparable piezoelectricity to the native bone without any post-treatment. The in vitro analyses demonstrated that nBT/CPS was biocompatible and could promote osteoblast differentiation. In conclusion, our results strongly indicate that the injectable formulation based on nBT/CPS can be a promising candidate in bone tissue engineering, and further research is needed to investigate the biomaterial's performance in bone defect animal models. |
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| Keywords: | Piezoelectric Injectable bone substitute Handleability Calcium phosphate silicate Bone tissue engineering |
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