Structural and biological properties of novel Vanadium and Strontium co-doped HAp for tissue engineering applications |
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| Affiliation: | 1. Department of Physics, Karunya Institute of Technology and Sciences, Coimbatore, India;2. Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, India;3. Department of Biotechnology, Cochin University of Science and Technology, Kalamassery, India;4. Department of Materials Sciences and Engineering, Advanced Materials Processing and Analysis Centre, University of Central Florida, Orlando, FL, USA;1. Materials and Structures Division, NASA Glenn Research Center, 21000 Brookpark Road, Cleveland, OH, 44135, USA;2. University of Toledo, Toledo, OH, USA;1. College of Chemistry and Chemical Engineering, Collaborative Innovation Center of Rare-Earth Functional Materials and Devices Development, Baoji University of Arts and Sciences, Baoji, 721016, China;2. College of Physics and Optoelectronic Technology, Baoji University of Arts and Sciences, Baoji, 721013, China;3. School of Physics, Xidian University, Xi''an, 710071, China;1. K1-MET GmbH, Linz, Stahlstraße 14, 4020, Austria;2. Technical University Bergakademie Freiberg, Freiberg, 09599, Germany;3. Montanuniversitaet Leoben, Leoben, 8700, Austria;1. School of Materials Science and Engineering, Jiangsu University of Science and Technology, Mengxi Road 2, Zhenjiang, Jiangsu Province, 212003, China;2. University of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering, Rua Luís Reis Santos, 3030-788, Coimbra, Portugal;3. Key Laboratory of Materials Physic, Institute of Solid State Physics, Hefei Institute of Physical Sciences, Chinese Academy of Sciences, Hefei, 230031, China;1. School of Materials Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, PR China;2. Wuxi DK Electronic Materials Co., Ltd, Wuxi, 214200, PR China;1. School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, China;2. School of Electromechanical Engineering, Lingnan Normal University, Zhanjiang, 524048, China |
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| Abstract: | The development of novel bioactive materials with improved physical and biological properties is crucial for advancing tissue engineering applications. In this study, we synthesized a Vanadium and Strontium co-doped hydroxyapatite (V–Sr:HAp) nanoparticle intending to enhance the performance of pure HAp. The V–Sr:HAp nanoparticles were synthesized using a microwave-assisted reflux condensation method, and their structural and chemical characteristics were investigated using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). The morphology and elemental composition of the nanoparticles were examined through scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDX). The XRD analysis confirmed the presence of characteristic peaks of HAp in each sample. SEM images revealed well-connected and highly agglomerated small sphere-like morphology in both pure HAp and V–Sr:HAp nanoparticles. The Vickers hardness test demonstrated the improved mechanical strength in V–Sr:HAp compared to pure HAp. Antibacterial efficacy was evaluated using an agar diffusion test, which showed enhanced antibacterial activity in the co-doped HAp samples against S. aureus and P. aeruginosa. Moreover, the Ca–P deposition rate on the surface of the co-doped HAp samples during biomineralization was higher. Hemolysis assay results have indicated compatibility of both pure HAp and V–Sr:HAp with human blood (<5% lysis). The results of cell viability tests demonstrate that the V and Sr co-doped HAp samples do not exhibit any cytotoxic effects and instead promote cell proliferation. Overall, the incorporation of V and Sr metal ions into HAp presents a promising bio-functional tool for tissue engineering applications, offering improved mechanical and antibacterial properties. |
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| Keywords: | Antibacterial activity Strontium Co-doped nanohydroxyapatite Vanadium Vickers hardness |
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