Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia |
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Authors: | R Przkora P Falkai A von Deimling OD Wiestler M Albus M Rietschel W Maier TA Bayer |
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Affiliation: | Clinica Dermatologica IV, Universitá degli studi di Milano, Ospedale San Paolo, Italy. |
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Abstract: | The tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of malformations in various organs including the brain. A polymorphism in the TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell migration pattern. Since these pathomorphological changes are compatible with disturbed neuronal migration in schizophrenic brains, we investigated this polymorphism in 130 families with a schizophrenic index patient. A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia. |
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