Vesicles from sucrose fatty acid esters |
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Authors: | Yutaka Ishigami Hajime Machida |
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Affiliation: | (1) National Chemical Laboratory for Industry, Tsukuba, 305 Ibaraki, Japan;(2) Central Laboratories, Mitsubishi Kasei Corp., Yokohama, Japan |
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Abstract: | It has been confirmed, from observations with an electron microscope after staining negatively with aqueous uranyl acetate
solutions and using a flourescent microscope, that sucrose fatty acid esters form closed vesicles. The range of particle size
of the vesicle, consisting of chromatographically fractionated sucrose dilaurate, was apparently 70–700 nm in the longer diameter
of individual vesicles based on the transmission electron microscopic (TEM) observation. The weight-average particle size
was 424 nm as shown by means of the photon-correlation method. The amounts of 6-carboxyfluorescein trapped in the vesicles
of sucrose fatty acid esters were determined, and it was ascertained that the volumes of the central water phase depended
upon the acyl chain lengths of fatty acid residues. Further, the effect of the additives cholesterol and dicetyl phosphate
(DCP) was examined. As an example, the vesicle of sucrose stearate had a central water phase of 1.7 one water/mol ester, and
showed a slow release of 6-carboxyfluorescein from the central water phase after preparation of the vesicle. |
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