Fabrication of microfluidic channels based on melt-electrospinning direct writing |
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Authors: | Jun Zeng Han Wang Yaru Lin Jiarong Zhang Feng Liang Feiyu Fang Fanwen Yang Ping Wang Ziming Zhu Xin Chen Xindu Chen Zhifeng Wang Nian Cai Yadong Tang Peixuan Wu |
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Affiliation: | 1.Guangdong Provincial Key Laboratory of Micro-nano Manufacturing Technology and Equipment, School of Electromechanical Engineering,Guangdong University of Technology,Guangzhou,China;2.School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou,China;3.School of Basic Sciences,Guangzhou Medical University,Guangzhou,China |
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Abstract: | Microfluidics is a flourishing field, enabling a wide range of applications. However, the current fabrication methods for creating the microchannel structures of microfluidic devices, such as photolithography and 3D printing, mostly have the problems of time-consuming, high cost or low resolution. In this work, we developed a simple and flexible method to fabricate PDMS microfluidic channels, based on poly(ε-caprolactone) (PCL) master mold additive manufactured by a technique termed melt-electrospinning direct writing (MEDW). It relies on the following steps: (1) direct writing of micrometric PCL 2D or 3D pattern by MEDW. (2) Casting PDMS on the printed PCL pattern. (3) Peeling off of patterned PDMS from the embedded sacrificial PCL layer. (4) Bonding the PDMS with microchannel to another PDMS layer by hot pressing. The process parameters during MEDW such as collector speed, nozzle dimension and temperature were studied and optimized for the quality and dimension of the printed micropatterns. Multilayer fiber deposition was developed and applied to achieve microscale architectures with high aspect ratio. Thus, the microchannels fabricated by the proposed approach could possess tunable width and depth. Finally, T-shape and cross-channel devices were fabricated to create either laminar flow or microdroplets to illustrate the applicability and potential of this method for microfluidic device manufacture. |
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