Antioxidant, antiacetylcholinesterase and antimicrobial activities of Cymbopogon schoenanthus L. Spreng (lemon grass) from Tunisia |
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Authors: | Ayda Khadri Mohamed Neffati Pedro Falé A Rosa L Lino M Eduarda M Araújo |
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Affiliation: | a University of El-Manar II, Faculty of Sciences, Unity of Research of Vegetal Ecology, Campus Academia, 2092 Tunis, Tunisia b Institute of the Arid Areas, Head of Range Ecology Laboratory, 4119 Medenine, Tunisia c University of Lisbon, Faculty of Sciences, Centre of Chemistry and Biochemistry, Campo Grande Ed. C8, 1749-016 Lisboa, Portugal d University of Lisbon, Faculty of Sciences, Centre Vegetal Biotechnology, Campo Grande Ed. C2, 1749-016 Lisboa, Portugal |
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Abstract: | Aqueous extract, proanthocyanidin rich extract, and organic extracts of Cymbopogon schoenanthus L. Spreng (lemon grass) shoots from three different locations in South Tunisia were screened for their antioxidant, acetylcholinesterase and antimicrobial activities. In addition to the evaluation of these activities, the contents of flavonoids and total phenolic compounds were determined.Antioxidant activity measured by DPPH assay showed that the proanthocyanidin extract exhibited higher antioxidant activity than the aqueous extract. Extract concentration providing 50% inhibition (IC50) ranged from 16.4 ± 6.8 μg/mL to 26.4 ± 6.8 μg/mL. The antioxidant activity was also determined using the β-carotene/linoleic acid bleaching test. The best results (IC50 = 0.11 ± 0.10 mg/mL) were obtained with the proanthocyanidin extract of the plants collected from the desert region (Dhibat).The greatest acetylcholinesterase inhibitory activity (IC50 = 0.23 ± 0.04 mg/mL) was exhibited by the ethyl acetate and methanol extracts of the plants collected from the mountainous region. It seems that extracts obtained with more polar solvents gave better results.The proanthocyanidin extracts showed a good antimicrobial activity against Streptococcus sobrinus at low concentration (MIC = 4 mg/mL). Therefore, these extracts could be used to prevent carious lesions by inhibiting S. sobrinus growth. |
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Keywords: | Cymbopogon schoenanthus Antioxidant activity Acetylcholinesterase inhibition Dental caries Streptococcus sobrinus |
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