固相萃取-高效液相色谱法测定纺织品中富马酸二甲酯

建立了纺织品中富马酸二甲酯的固相萃取-高效液相色谱检测方法。样品经超声提取后，用固相萃取进行净化，Kromasil C18 柱（250 mm × 4.6 mm i.d., 5 μm）分离，采用乙腈+水(55+45, V/V)为流动相，紫外检测波长为220 nm，外标法定量。实验结果表明：富马酸二甲酯在0.05~50.0 mg/L的浓度范围内呈良好的线性关系，最低检出限LOD为0.05mg/kg，定量检出限LOQ为0.15 mg/kg 。方法回收率在91.2~102.1%之间，平均回收率为96.4%，RSD 为1.3~3.9% 。所建实验方法快速、简便、干扰少，能满足纺织品中富马酸二甲酯的测定要求。

Determination of dimethyl fumarate in textiles by solid phase extraction- high-performance liquid chromatography

To establish a method for the determination of dimethyl fumarate in textiles by solid phase extraction- high performance liquid chromatography. The samples were used by Ultrasonic Extraction, cleaned and enriched by a Sep-Pak? Vac Silica solid-phase extraction(SPE) cartridge, separated on a Kromasil C18 column（250 mm × 4.6 mm i.d., 5 μm）by using the mobile phase consisting of CH3CN+H2O (55+45, V/V) . Detection was performed by 220 nm using extenal standard method. The result of experiment shows that calibration curve of dimethyl fumarate was linear within the range of 0.05~50.0 mg/L , the limit of detection was found to be 0.05mg/kg,and the limit of quantification was found to be 0.15 mg/kg. The extraction recoveries were at 91.2 ~ 102.1% , average recoverywas 96.4% and the RSDs were at 1.3~3.9%. The developed method is quick，simple, little interferential for the determination of dimethyl fumarate residue in textiles.