Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization |
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Authors: | Antonio Bertoletti Nina Le Bert Anthony T. Tan |
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Affiliation: | Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore |
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Abstract: | The emergence of new SARS-CoV-2 lineages able to escape antibodies elicited by infection or vaccination based on the Spike protein of the Wuhan isolates has reduced the ability of Spike-specific antibodies to protect previously infected or vaccinated individuals from infection. Therefore, the role played by T cells in the containment of viral replication and spread after infection has taken a more central stage. In this brief review, we will discuss the role played by T cells in the protection from COVID-19, with a particular emphasis on the kinetics of the T cell response and its localization at the site of primary infection. |
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Keywords: | adaptive immunity against SARS-CoV-2 tissue-resident T cells |
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