Stem Cell Therapy for Sequestration of Traumatic Brain Injury-Induced Inflammation |
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| Authors: | Mia C. Borlongan Susanna Rosi |
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| Affiliation: | 1.Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA 94143, USA;2.Brain and Spinal Injury Center, University of California, San Francisco, CA 94110, USA;3.Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA;4.Weill Institute for Neuroscience, University of California, San Francisco, CA 94158, USA |
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| Abstract: | Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disabilities in the world. TBI is a signature disease for soldiers and veterans, but also affects civilians, including adults and children. Following TBI, the brain resident and immune cells turn into a “reactive” state, characterized by the production of inflammatory mediators that contribute to the development of cognitive deficits. Other injuries to the brain, including radiation exposure, may trigger TBI-like pathology, characterized by inflammation. Currently there are no treatments to prevent or reverse the deleterious consequences of brain trauma. The recognition that TBI predisposes stem cell alterations suggests that stem cell-based therapies stand as a potential treatment for TBI. Here, we discuss the inflamed brain after TBI and radiation injury. We further review the status of stem cells in the inflamed brain and the applications of cell therapy in sequestering inflammation in TBI. |
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| Keywords: | trauma traumatic brain injury stem cell-based therapy resident stem cells neurogenesis inflammation brain repair |
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