Microfluidic device for continuous magnetophoretic separation of white blood cells |
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Authors: | Ciprian Iliescu Guolin Xu Elena Barbarini Marioara Avram Andrei Avram |
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Affiliation: | (1) Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore, 639798, Singapore;(2) Electronics Department, Politecnico di Torino, 24, Corso Duca degli Abruzzi, 10129 Torino, Italy;(3) National Institute for Research and Development in Microtechnologies, Erou Iancu Nicolae Str., 32 B, Bucharest, Romania |
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Abstract: | This paper presents a microfluidic device for magnetophoretic separation of red blood cells from blood under continuous flow. The separation method consists of continuous flow of a blood sample (diluted in PBS) through a microfluidic channel which presents on the bottom “dots” of ferromagnetic layer. By applying a magnetic field perpendicular on the flowing direction, the ferromagnetic “dots” generate a gradient of magnetic field which amplifies the magnetic force. As a result, the red blood cells are captured on the bottom of the microfluidic channel while the rest of the blood is collected at the outlet. Experimental results show that an average of 95% of red blood cells is trapped in the device. |
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