粉末冶金制备TNZS基生物材料的体外组织相容性

采用高能球磨与冷压烧结相结合的粉末冶金法制备了TNZS、5%TiO_2/TNZS及5%HA/TNZS(质量分数,下同)生物材料,并研究了TiO_2和HA的添加对TNZS体外组织相容性的影响。结束表明:3种TNZS基生物材料均无细胞毒性;5%TiO_2/TNZS和5%HA/TNZS表面在1,3,5和7 d的细胞相对增殖抑制率CPIR值大幅低于TNZS组,TiO_2和HA的添加显著提高了TNZS材料表面的细胞增殖速度,增强了其细胞增殖能力,更有助于诱导成骨细胞的体外增殖;3种TNZS基材料表面贴附的成骨细胞伪足伸展状态良好,而5%TiO_2/TNZS表面贴附的成骨细胞分布更加均匀。

Histocompatibility in vitro of TNZS-based biomaterials prepared by powder metallurgy

TNZS, TiO2/TNZS and HA/TNZS bio-medical materials were prepared by powder metallurgy comebining high-energy milling with cold pressed sintering. Histocompatibility in vitro of the three TNZS-based materials were studied. The results show that: three materials have no cytotoxicity, meeting toxicity safety requirements of implant materials; CPIR on the surface of TiO2/TNZS and HA/TNZS for 1 d, 3 d, 5 d and 7 d have significantly lower than that of TNZS group, showing that the addition of TiO2 and HA can improve the speed of cell proliferation on the surface of TNZS material and have better induction of proliferation of osteoblasts in vitro; the distribution of osteoblasts attached to the surface of TiO2/TNZS has more uniform; pseudopodium extension of osteoblasts attached to the surface of three materials are in good condition.