Synthesis and biological investigation of novel tricyclic benzodiazepinedione-based RGD analogues |
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Authors: | Addicks Elisabeth Mazitschek Ralph Giannis Athanassios |
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Affiliation: | Institut für Organische Chemie Universit?t Leipzig, Johannisallee 29 04103 Leipzig, Germany. |
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Abstract: | Integrins, a widely expressed family of heterodimeric cell surface adhesion proteins, are expressed in a variety of cell types. They play a decisive role in cell-cell adhesion or cell to extracellular matrix adhesion events. Antagonists of alpha(v)beta(3) or alpha(IIb)beta(3) integrin may have a potential use in suppression of pathological processes. We present the synthesis of novel tricyclic benzodiazepinedione-based RGD analogues, which were subsequently tested in a solid-phase receptor assay in order to investigate their binding affinities towards alpha(v)beta(3) and alpha(IIb)beta(3) integrin. |
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