Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis,characterization and magnetic heating efficiency |
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Authors: | P. H. Linh N. V. Chien D. D. Dung P. H. Nam D. T. Hoa N. T. N. Anh L. V. Hong N. X. Phuc P. T. Phong |
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Affiliation: | 1.Institute of Materials Science,Vietnam Academy of Science and Technology,Hanoi,Vietnam;2.School of Engineering Physics,Ha Noi University of Science and Technology,Hanoi,Vietnam;3.Duy Tan University,Da Nang City,Vietnam;4.Theoretical Physics Research Group, Advanced Institute of Materials Science,Ton Duc Thang University,Ho Chi Minh City,Vietnam;5.Faculty of Applied Sciences,Ton Duc Thang University,Ho Chi Minh City,Vietnam |
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Abstract: | In this work, we developed a polymer encapsulation of Fe3O4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles were synthesized by microwave-assisted co-precipitation. The cluster sizes were tunable by varying the concentration of polymers used during synthesis. Nanoclusters present superparamagnetic behavior at room temperature with a reduction in saturation magnetization as a consequence of coating layer. The shift of blocking temperature to the higher value with increasing clusters size shows the stronger magnetic interaction in larger magnetic clusters. In a low alternating magnetic field with frequency of 178 Hz and amplitude of 103 Oe, nanoclusters offer a high heating efficiency. A maximum specific absorption rate of 204 W/g is observed in the sample with hydrodynamic size of 53 nm. In vitro cytotoxicity analysis performed on HeLa cells verified that nanoclusters show a good biocompatibility and can be an excellent candidate for applications in hyperthermia cancer treatment. |
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