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Bacterial cell killing properties of silver-loaded polysiloxane microspheres
Authors:Urszula Mizerska  " target="_blank">Rafal Halasa  " target="_blank">Katarzyna Turecka  " target="_blank">Julian Chojnowski  " target="_blank">Piotr Pospiech  " target="_blank">Witold Fortuniak  " target="_blank">Stanislaw Slomkowski  " target="_blank">Tomasz Makowski  " target="_blank">Waldemar Machnowski  " target="_blank">Przemyslaw Sowinski
Affiliation:1.Centre of Molecular and Macromolecular Studies,Polish Academy of Sciences,Lodz,Poland;2.Chair and Department of Pharmaceutical Microbiology, Faculty of Pharmacy with Subfaculty of Laboratory Medicine,Medical University of Gdansk,Gdańsk,Poland;3.Department of Material and Commodity Sciences and Textile Metrology,Lodz University of Technology,Lodz,Poland
Abstract:Cross-linked polysiloxane microspheres containing a large number of SiOH groups were modified by introduction of organic thiol groups, which were further used for the functionalization of the microspheres with silver thiolate groups. The microspheres were characterized by 29Si MAS NMR, 13C MAS NMR, SEM, XPS and elemental analysis. They were tested as biocides against selected Gram-positive and Gram-negative bacteria strains and exhibited high bactericidal activity. Separately, linear polysiloxane polymers equipped with organothiol groups and loaded with silver were synthesized. Their antibacterial activity was compared with that of silver thiolate-functionalized microspheres. Different shape of particles and a different form of silver explained somewhat lower activity of polymers.
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