| 药物诱发白鼠肝病变过程中白鼠血清光谱的研究 |
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| 引用本文： | 刘华生 陈丹梅 等. 药物诱发白鼠肝病变过程中白鼠血清光谱的研究[J]. 激光杂志, 2001, 22(5): 70-72 |
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| 作者姓名： | 刘华生 陈丹梅 等 |
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| 作者单位： | [1]大连理工大学应用物理研究所 [2]大连理工大学医院 |
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| 摘 要： | 本文用激光诱导荧光的方法，研究了药物诱发白鼠肝病变过程中不同阶段的白鼠的血清光谱。实验结果表明，用514．5nm作激发光源，白鼠从正常经肝纤维化到肝硬化的过程中，血清光谱的荧光峰有红移现象，而用488．0nm作激光源的光谱之间则无明显的差别。此外，研究发现CCl4溶液对白鼠肝硬化的诱发量为有效。
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| 关 键 词： | 荧光光谱 血清光谱 药物诱发 白鼠肝病变过程 |
Study of rats' sera spectra during the progression of liver abnormalities induced by different materials |
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| Liu Huasheng Ding Jianhua Jiao Xiying Chen Danmei Zhu Ying Zhao Gang. Study of rats' sera spectra during the progression of liver abnormalities induced by different materials[J]. Laser Journal, 2001, 22(5): 70-72 |
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| Authors: | Liu Huasheng Ding Jianhua Jiao Xiying Chen Danmei Zhu Ying Zhao Gang |
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| Affiliation: | Liu Huasheng 1 Ding Jianhua 1 Jiao Xiying 1 Chen Danmei 2 Zhu Ying 3 Zhao Gang 4 |
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| Abstract: | Serum spectra of rats during the progression of liver abnormalities induced by alcohol,CCL 4 and albumen are investigated in this study.Compared with results of pathological examination,we analyse the spectra of normal cases,hepatic fibrosis and hepatocirrhosis respectively in an attempt to find some differences between them.Red shift of fluorescence peak is observed with disease evolution using 514.5nm excitation of an Ar ion laser.However,no distinct changes happen with 488.0nm excitation.In addition,results show that CCL 4 solution is the most effective material for hepatic disease inducement. |
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| Keywords: | fluorescence spectrum serum liver CCL 4 solution laser |
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