Dietary protein modulates the effect of CLA on lipid metabolism in rats |
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Authors: | Asuka Akahoshi Kazunori Koba Fumika Ichinose Mai Kaneko Asako Shimoda Kikuko Nonaka Masao Yamasaki Toshio Iwata Yoshie Yamauchi Kentaro Tsutsumi Michihiro Sugano |
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Affiliation: | (1) Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Nagayo, 851-2195 Nagasaki, Japan;(2) Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Graduate School Kyushu University, 812-8581 Kukuoka, Japan;(3) Department of Research and Development, Rinoru Oils Mills Co., 104-0033 Tokyo, Japan;(4) Faculty of Environmental and Symbiotic Sciences, Pretectural University of Kumamoto, 3-1-100 Tsukide, 862-8502 Kumamoto, Japan |
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Abstract: | The effect of the interaction of CLA and type of dietary protein on lipid metabolism was studied in male rats by feeding diets
containing casein (CAS) or soy protein (SOY) as dietary protein and either linoleic acid (LA, a control FA) or graded levels
of CLA at 0,0.1, 0.5, and 1.0% for 28 d. CLA reduced the weight of perirenal adipose tissue in a dose-dependent manner, but
the magnitude of the reduction was greater when rats were fed SOY. Feeding SOY resulted in a significant reduction of the
concentrations of serum total and HDL cholesterol, TG, glucose, and insulin irrespective of dietary CLA. The concentration
of serum leptin tended to be lower on the SOY diet free of CLA than in the corresponding CAS diet, but it fell with an increasing
dietary level of CLA in the CAS groups. In contrast, serum leptin tended to increase when CLA was added to SOY diets. The
concentration of serum adiponectin was higher in the CAS than in the SOY groups, and it tended to increase in response to
dietary CLA levels in the CAS-fed rats, whereas CLA showed no effect in SOY-fed rats. The activity of liver mitochondrial
carnitine palmitoyltransferase was higher in the SOY than in the CAS groups, but it tended to increase with an increasing
dietary level of CLA in both protein groups. Although the body fat-reducing activity of CLA was more effective when the protein
source was SOY, rats fed CAS appeared to be more susceptible to CLA than in those fed SOY with respect to cytokines examined.
These results suggest that the type of dietary protein may modify the antiobesity activity of CLA. |
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