中国居民白酒中氨基甲酸乙酯健康风险概率评估

目的了解我国居民白酒中氨基甲酸乙酯的暴露状况并对其健康风险进行评估。方法利用2002年中国居民营养与健康状况调查18岁及以上人群白酒消费量数据和2010—2011年全国25省白酒中氨基甲酸乙酯调查数据,采用@Risk软件对人群白酒氨基甲酸乙酯健康风险进行概率风险评估。结果 2010—2011年白酒中氨基甲酸乙酯的平均含量为0.072 mg/kg。18岁以上人群白酒氨基甲酸乙酯每日平均暴露量为8.09 ng/kg BW,暴露限值为37 083,个体暴露限值超过引起公共卫生关注度的概率为0.052。白酒饮酒者氨基甲酸乙酯每日平均暴露量为159.99 ng/kg BW,暴露限值为1 875,饮酒者个体暴露限值超过引起公共卫生关注度的概率为0.455。结论18岁及以上人群白酒氨基甲酸乙酯暴露的健康风险较低,但白酒饮酒者存在较高健康风险。

Probabilistic risk assessment of ethyl carbamate in spirits among Chinese population

To explore the ethyl carbamate level in the spirits and assess the health risk of ethyl carbamate exposure among Chinese population.Methods The @Risk software was introduced and probabilistic assessment method was adopted to assess the risk of ethyl carbamate exposure from spirits consumption. The ethyl carbamate concentration data was derived from national food safety risk surveillance system between 2010 and 2011, and the spirits consumption data of population aged 18 and above was collected in Chinese nutrition and health survey 2002.Results The mean value of ethyl carbamate in spirits were 0.072 mg/kg. The average intake of ethyl carbamate and the margin of exposure (MOE) value among people aged 18 and above were 8.09 ng/kg BW per day and 37 083 respectively. However, the average intake of spirits consumers was 159.99 ng/kg BW per day and the margin of exposure value was 1 875. The probability of individual margin of exposure exceeding the level of public health concern was 0.052 and 0.455 for the whole population aged 18 and above and spirits consumers respectively.Conclusion For the people aged 18 and above, the health risk of ethyl carbamate exposure from spirits was of low concern, however, there was a quite high health risk caused by ethyl carbamate intake among spirits consumers.