| Alkylated and silylated β-cyclodextrin for gas chromatographic chiral stationary phases |
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| 引用本文： | 唐课文,易健民,周春山.Alkylated and silylated β-cyclodextrin for gas chromatographic chiral stationary phases[J].中南工业大学学报(英文版),2002,9(2):95-99. |
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| 作者姓名： | 唐课文 易健民 周春山 |
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| 作者单位： | [1]CollegeofChemistryandChemicalEngineering,CentralSougtUniversity,Changsha410083,China [2]CollegeofChemistryandChemicalEngineering,CentralSougtUniversity,Changsha410083,China／／DepartmentofChemistryandChemicalEngineering,YueyangNormalUniversity,Yueyang414000,China [3]DepartmentofChemistryandChemicalEngineering,YueyangNormalUniversity,Yueyang414000,China |
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| 摘 要： | Three new ehiral stationary phases, 2, 6-di-O-heptyl-3-O-trimethylsilyl-β-cyclodextrin( DHTBCD), 2,6-di-O-pentyl-3-O-trimethylsilyl-β-cyclodextrin (DPTBCD) and 2,6-di-O-butyl-3-O-trimethylsilyl-β-cyclodextrin (DBTBCD), were synthesized. Chromatographie properties sueh as eolumn efficieney, thermal stability and eolumn life span, were studied. The separations of enantiomers, sueh as ketone, esters, alcohols and olefines, were investigated on the alkylated and silylated β-eyelodextrin stationary phases. The influenee of diluent on ehiral separation was studied. The experimental results indieate that the stationary phases show good ehromatographie properties in separating enantiomers. It is observed that inelusion eomplexafion and hydrogen bonding interaction hardly play a role in separating enantiomers.
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| 关 键 词： | 气相色谱 手性固定相 烷化物 β-环糊精 DBTBCD DPTBCD |
| 收稿时间： | 9 August 2001 |
Alkylated and silylated β-cyclodextrin for gas chromatographic chiral stationary phases |
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| Tang Ke-wen , Yi Jian-ming and Zhou Chun-shan.Alkylated and silylated β-cyclodextrin for gas chromatographic chiral stationary phases[J].Journal of Central South University of Technology,2002,9(2):95-99. |
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| Authors: | Tang Ke-wen Yi Jian-ming and Zhou Chun-shan |
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| Affiliation: | (1) College of Chemistry and Chemical Engineering, Central South University, 410083 Changsha, China;(2) Department of Chemistry and Chemical Engineering, Yueyang Normal University, 414000 Yueyang, China |
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| Abstract: | Three new chiral stationary phases, 2,6-di-O-heptyl-3-O-trimethylsilyl-β-cyclodextrin (DHTBCD), 2,6-di-O-pentyl-3-O-trimethylsilyl-β-cyclodextrin
(DPTBCD) and 2,6-di-O-butyl-3-O-trimethylsilyl-β-cyclodextrin (DBTBCD), were synthesized. Chromatographic properties such
as column efficiency, thermal stability and column life span, were studied. The separations of enantiomers, such as ketone,
esters, alcohols and olefines, were investigated on the alkylated and silylated β-cyclodextrin stationary phases. The influence
of diluent on chiral separation was studied. The experimental results indicate that the stationary phases show good chromatographic
properties in separating enantiomers. It is observed that inclusion complexation and hydrogen bonding interaction hardly play
a role in separating enantiomers.
Foundation item: The Natural Science Foundation of Hunan Province (No. 01JJY2098)
Biography of the first author: TANG Ke-wen, doctoral student, born in 1970, majoring in applied chemistry. |
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| Keywords: | cyclodextrin derivatives capillary gas chromatography enantiomeric separation |
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