| 3-氯-4-氟硝基苯的微波合成法 |
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| 引用本文： | 罗军,吕春绪.3-氯-4-氟硝基苯的微波合成法[J].精细化工中间体,2007,37(1):30-33. |
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| 作者姓名： | 罗军 吕春绪 |
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| 作者单位： | 南京理工大学,化工学院,江苏,南京,210094 |
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| 摘 要： | 研究了以3,4-二氯硝基苯为原料通过卤素交换氟化合成3-氯-4-氟硝基苯的反应。结果表明，微波加热条件下反应速率是常规加热的3～12倍。收率和选择性也都有提高。金属Lewis酸A1C13和SbCl3用作本反应的催化剂可以取得良好的效果，其中SbCl3效果最好，用于400W微波加热反应10min可得到97．0％的收率。
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| 关 键 词： | 3 4-二氯硝基苯 3-氯-4-氟硝基苯 微波 氟化 LEWIS酸 |
| 文章编号： | 1009-9212(2007)01-0030-04 |
| 修稿时间： | 2006-08-18 |
Synthesis of 3-Chloro-4-fiuoronitrobenzene Promoted by Microwave Irradiation |
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| LUO Jun,L Chun-xu.Synthesis of 3-Chloro-4-fiuoronitrobenzene Promoted by Microwave Irradiation[J].Fine Chemical Intermediates,2007,37(1):30-33. |
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| Authors: | LUO Jun L Chun-xu |
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| Affiliation: | School of Chemical Engineering, Nanjing University of Science and Technology, Nanijng 210094, China |
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| Abstract: | 3-Chloro-4-fluoronitrobenzene was prepared from 3,4-dichloronitrobenzene through halogen-exchange fluorination. The reaction rate under microwave heating was 3~12 times higher than that under conventional heating, and the yield and selectivity increased as well. AlCl3 and SbCl3 were applied in this reaction to give excellent results. The best result was obtained in a high yield of 97.0% when 400 W microwaves were used for 10 min. |
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| Keywords: | 3 4-dichloronitrobenzene 3-chloro-4-fluoronitrobenzene microwave fluorination Lewis acid |
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