首页 | 本学科首页   官方微博 | 高级检索  
     

水溶液中新核心[99Tcm(CO)2(NO)]2+和[99Tcm(CO)2(NO)-L] (L=DTPA,EDTA,EHIDA)的制备
引用本文:刘晶莹,杨洋,朱霖. 水溶液中新核心[99Tcm(CO)2(NO)]2+和[99Tcm(CO)2(NO)-L] (L=DTPA,EDTA,EHIDA)的制备[J]. 核化学与放射化学, 2009, 31(2): 90-97
作者姓名:刘晶莹  杨洋  朱霖
作者单位:教育部放射性药物重点实验室,北京师范大学 化学学院,北京 100875
基金项目:高等学校博士学科点专项科研基金 
摘    要:研究了水溶液中制备[99Tcm(CO)2(NO)-L](L=DTPA,EDTA,EHIDA)配合物的2种方法:(1) 由前体[99Tcm(CO)3-L]制备[99Tcm(CO)2(NO)-L];(2)由[99Tcm(CO)2(NO)(H2O)3]2+中间体制备[99Tcm(CO)2(NO)-L];并确定了最佳标记条件.TLC和HPLC结果表明,2种方法得到的配合物放化产率均在90%以上.初步建立了1套在水溶液中简单、高效制备新的[99Tcm(CO)2(NO)]2+类配合物的方法.+基团取代原三羰基锝配合物得到的[99Tcm (CO)2(NO)-L]配合物具有良好的体外稳定性,取代后的配合物脂溶性和电荷性质都发生了改变,为99Tcm放射性药物的研制开辟了新思路.

关 键 词:[99Tcm(CO)2(NO)-L]配合物  [99Tcm(CO)2(NO)(H2O)3]2+中间体  制备方法  标记条件  理化性质  

Preparation of New Core [99Tcm(CO)2(NO)]2+ and Its Derivatives [99Tcm(CO)2(NO)-L] (L=DTPA,EDTA,EHIDA) in Aqueous Solution
LIU Jing-ying,YANG Yang,ZHU Lin. Preparation of New Core [99Tcm(CO)2(NO)]2+ and Its Derivatives [99Tcm(CO)2(NO)-L] (L=DTPA,EDTA,EHIDA) in Aqueous Solution[J]. Journal of Nuclear and Radiochemistry, 2009, 31(2): 90-97
Authors:LIU Jing-ying  YANG Yang  ZHU Lin
Affiliation:Key Laboratory of Radiopharmaceuticals (Ministry of Education), College of Chemistry, Beijing Normal University, Beijing 100875, China
Abstract:In order to develop a new method for the preparation of the [99Tcm (CO)2(NO)-L] (L=DTPA, EDTA, EHIDA) complexes in aqueous solution, two different procedures were developed: one is formation of the metal-tricarbonyl-ligand complex and subsequent nitrosylation; another is nitrosylation of the metal- tricarbonyl precursor followed by reaction with the ligand. The optimal labeling conditions were studied. Results of TLC and HPLC indicate that the radiochemical yields derived from the two methods list above are all more than 90%. It’s an easier new way to prepare [99Tcm (CO)2(NO)-L] complexes in aqueous solution with high efficiency. The newly developed [99Tcm (CO)2(NO)-L] complexes are stable at room temperature during 1 half-life of the isotope. At the same time, the lipophility and net charge of [99Tcm (CO)2(NO)-L]complexes are also changed comparing with that of corresponding [99Tcm(CO)3]+core complexes. It opens a new field for designing radiopharmaceuticals. 
Keywords:
本文献已被 维普 万方数据 等数据库收录!
点击此处可从《核化学与放射化学》浏览原始摘要信息
点击此处可从《核化学与放射化学》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号