How is the intracellular fate of the Legionella pneumophila phagosome determined? |
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Authors: | G Segal HA Shuman |
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Affiliation: | Wellcome/CRC Institute, Cambridge, UK. |
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Abstract: | The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered. |
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