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A control theoretic approach to malaria immunotherapy with state jumps |
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| Authors: | H. Chang A. Astolfi H. Shim[Author vitae] |
| Affiliation: | aDepartment of Mechanical Engineering, Boston University, MA 02215, United States;bDepartment of Electrical and Electronic Engineering, Imperial College London, UK;cDipartimento di Informatica, Sistemi e Produzione, Università di Roma Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy;dASRI, Department of Electrical Engineering, Seoul National University, Seoul, Republic of Korea |
| Abstract: | We investigate a control method for malaria dynamics to boost the immune response using a model-based approach. The idea of state jump is introduced and discussed using a hybrid model. To implement the state jumps we use a physiologically feasible method for the biological system, whereby the introduction of a pathogen into the system steers it to a desirable status. It is noted that we take advantage of a pathogen to implement state jumps in the system. The study is supported by recently reported experimental results. |
| Keywords: | Malaria Immunotherapy Hybrid systems State jump Impulsive control |
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