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Plasmonic Superparamagnetic SPION@Ag@chitosan Core-shell: Uptake and Nitric Oxide Inhibition by Colorectal Cell Lines |
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| Authors: | Eid M M Ismail A M Elshahid Zeinab A Elzaher Fatma H Abd Mahmoud K El-Manawaty M |
| Affiliation: | 1.Physics Division, Spectroscopy Department, National Research Centre, Dokki, 12622, Giza, Egypt ;2.Chemistry of Natural and Microbial Products, Pharmaceutical Industry Research Division, National Research Centre, Dokki, 12622, Giza, Egypt ;3.Agricultural and Biological Division, Agricultural Microbiology Department, National Research Centre, Dokki, 12622, Giza, Egypt ;4.Pharmaceutical Sciences Division, Department of Pharmacognosy, National Research Centre, Dokki, 12622, Giza, Egypt ; |
| Abstract: | Using Fusarium oxysporum species (F. oxysporum), a green synthesis of super-paramagnet iron oxide @silver@ Chitosan (SPION@Ag@Cs) was achieved. The physico-chemical characteristics of the SPION@Ag@Cs nanocomposite revealed the development of superparamagnetic phases of iron oxide (Fe2O3), as well as fluorescence, Raman absorption, and biocompatibility. Drug and gene delivery, and diagnosis, are all possibilities for the nanocomposite. The uptake of nitric oxide by HT-29 colorectal cell lines is examined in this article, for up to 72 h, the cytotoxicity of the HCT116 cell line was investigated. These characteristics were compared to Streptomyces griseus fungal species (S. griseus) which develops Fe3O4 under the same preparation conditions. |
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