Magneto-plasmonic heterodimers: Evaluation of different synthesis approaches |
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Authors: | Marta Miola Cristina Multari Doriana Debellis Francesco Laviano Roberto Gerbaldo Enrica Vernè |
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Affiliation: | 1. Department of Applied Science and Technology, Politecnico di Torino, Torino, Italy;2. Electron Microscopy Facility, Istituto Italiano di Tecnologia, Genova, Italy |
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Abstract: | Nanomedicine has gained huge attention in recent years with new approaches in medical diagnosis and therapy. Particular consideration has been devoted to the nanoparticles (NPs) in theranostic field with specific interest for magnetic and gold NPs (MNPs and GNPs) due to their peculiar properties under exposition to electromagnetic fields. In this paper, we aim to develop magneto-plasmonic heterodimer by combining MNPs and GNPs through a facile and reproducible synthesis and to investigate the influence of different synthesis parameters on their response to magnetic and optical stimuli. In particular, various syntheses were performed by changing the functionalization step and using or not a reducing agent to obtain stable NP suspensions with tailored properties. The obtained heterodimers were characterized through physical, chemical, optical, and magnetic analysis, in order to evaluate their size, shape, plasmonic properties, and superparamagnetic behavior. The results revealed that the shape and dimensions of the nanocomposites can be tuned by MNPs surface functionalization, as well as by the use of a reducing agent, giving rise to nanoplatform suitable for biomedical application, exploiting the gold absorbing peak in the specific gold absorbing range of GNPs, while maintaining the superparamagnetic behavior typical of the MNPs. The obtained nanocomposites can be proposed as potential candidates for cancer theranostics. |
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Keywords: | gold nanoparticles magnetite nanoparticles magneto-plasmonic heterodimers tannic acid |
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