Epigenetic Changes in Gestational Diabetes Mellitus |
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| Authors: | Dominik Franciszek D&#x;uski Ewa Woli&#x;ska Maciej Skrzypczak |
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| Affiliation: | 1.Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Street: Jaczewskiego 8, 20-954 Lublin, Poland;2.Department of Pathology, Medical University of Warsaw, Street: Żwirki i Wigury 61, 02-091 Warsaw, Poland;3.II Chair and Department of Gynecology, Medical University of Lublin, Street: Jaczewskiego 8, 20-954 Lublin, Poland; |
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| Abstract: | Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is for the first time diagnosed during pregnancy. It can lead to many complications in the mother and in the offspring, so diagnostics and management of GDM are important to avoid adverse pregnancy outcomes. Epigenetic studies revealed the different methylation status of genes in pregnancies with GDM compared to pregnancies without GDM. A growing body of evidence shows that the GDM can affect not only the course of the pregnancy, but also the development of the offspring, thus contributing to long-term effects and adverse health outcomes of the progeny. Epigenetic changes occur through histone modification, DNA methylation, and disrupted function of non-coding ribonucleic acid (ncRNA) including microRNAs (miRNAs). In this review, we focus on the recent knowledge about epigenetic changes in GDM. The analysis of this topic may help us to understand pathophysiological mechanisms in GDM and find a solution to prevent their consequences. |
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| Keywords: | gestational diabetes mellitus DNA methylation epigenetics histone modification non-coding RNAs |
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