| 由靛红简易合成9-氨基-1,2,3,4-四氢吖啶 |
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| 引用本文： | 李加荣,周馨我,陈鹏,郭永建. 由靛红简易合成9-氨基-1,2,3,4-四氢吖啶[J]. 北京理工大学学报(英文版), 2002, 11(4): 375-377. DOI: 10.3969/j.issn.1004-0579.2002.04.009 |
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| 作者姓名： | 李加荣 周馨我 陈鹏 郭永建 |
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| 作者单位： | 北京理工大学,化工与材料学院,北京,100081;北京理工大学,化工与材料学院,北京,100081;北京理工大学,化工与材料学院,北京,100081;北京理工大学,化工与材料学院,北京,100081 |
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| 摘 要： | 由靛红出发,经由靛红3-肟和2-氨基苯甲氰合成9-氨基-1,2,3,4-四氢吖啶,产率68.1%. 靛红-3-肟的热分解催化剂为甲醇钠,环丁砜用作溶剂.目标化合物的结构表征方法包括元素分析、红外、核磁和质谱等.
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| 关 键 词： | 合成 老年痴呆病 热分解 缩合 |
| 收稿时间： | 2002-01-19 |
A Facile Synthesis of 9-Amino-1,2,3,4- Tetrahydroacridine from Isatin |
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| LI Jia-rong,ZHOU Xin-wo,CHEN Peng and GUO Yong-jian. A Facile Synthesis of 9-Amino-1,2,3,4- Tetrahydroacridine from Isatin[J]. Journal of Beijing Institute of Technology, 2002, 11(4): 375-377. DOI: 10.3969/j.issn.1004-0579.2002.04.009 |
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| Authors: | LI Jia-rong ZHOU Xin-wo CHEN Peng GUO Yong-jian |
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| Affiliation: | School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China |
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| Abstract: | Tacrine(9-amino-1,2,3,4-tetrahydroacridine) was synthesized using isatin as the raw material through isatin 3-oxime and 2-aminobenzonitrile with a yield of 68.1%. Sodium methoxide was used as the catalyst in the thermal decomposition of isatin 3-oxime, and tetramethylene sulfone was used as the solvent. The structure of tacrine was determined by IR, 1H NMR, MS and elemental analysis. |
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| Keywords: | synthesis Alzheimer's disease thermal-decomposition condensation |
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