硒强化剂的急性和蓄积毒性试验研究

为安全生产补硒保健食品和保障食品安全提供科学参考依据.用保健食品常见的硒强化剂亚硒酸钠对小鼠进行不同剂量灌胃,通过急性和蓄积性毒性试验, 系统研究硒对小鼠生长性能,组织病理变化,血常规、血液生化指标等的影响,建立小鼠硒中毒的动物模型.急性毒性试验表明:小鼠经口LD50为3.86 mg/kg;蓄积性毒性试验表明亚硒酸钠对小鼠有弱蓄积性.

Experiment on Acute and Accumulative Toxicity Test of Selenium Reinforcement

The objective of this study was to provide enough scientific evidence and reference for the non-polluted meat products and the food supervision department.For this,the Kun Ming mice were taken as animal models and were filled Sodium Selenium of health foods in the stomach in order to perform the acute and accumulative toxicity experiment.The effect of selenium to the animals growth performance,pathological change,blood biochemical and routine indexes was carefully investigated and the results demonstrated that :The LD50 was 3.86mg/kg and selenium was weak accumulative toxicity to mice.