| 一种SGLT-2抑制齐UErtugliflozin关键中间体的简便合成 |
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| 引用本文： | 杨清鑫,杨靖翔,刘亦斌,李兴伟,陈友喜,张春桃.一种SGLT-2抑制齐UErtugliflozin关键中间体的简便合成[J].化工时刊,2013,27(4):21-24. |
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| 作者姓名： | 杨清鑫 杨靖翔 刘亦斌 李兴伟 陈友喜 张春桃 |
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| 作者单位： | 1. 湖南中医药大学 湖南长沙410208
2. 上海阳帆医药科技有限公司 上海201203 |
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| 摘 要： | 报道了一种以2-氯-5-溴苯甲酸为底物经酰化，还原，甲酰化等多步反应得到4-氯-3-（4一乙氧基苄基）苯甲醛的简便合成，提供了一种SGLT-2抑制剂Ertuglitlozin关键中间体的新合成方法，该方法所用原料和试剂廉价易得，合成路线简洁，操作简便，收率高，有利降低生产成本，提高生产效率。
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| 关 键 词： | SGLT-2抑制剂Ertuglitlozin 2-氯-5-溴苯甲酸甲酰化 |
New Method for the Synthesis of 3-aryl-2,5-Dihydrofurans |
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| Yang Qingxin
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Yang Jingxiang
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Liu Yibin
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Li Xingwei
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Chen Youxi
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Zhang Chuntao.New Method for the Synthesis of 3-aryl-2,5-Dihydrofurans[J].Chemical Industry Times,2013,27(4):21-24. |
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| Authors: | Yang Qingxin Yang Jingxiang Liu Yibin Li Xingwei Chen Youxi Zhang Chuntao |
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| Affiliation: | Yang Qingxin Yang Jingxiang Liu Yibin* Li Xingwei* Chen Youxi* Zhang Chuntao(Hunan University of Chinese Medicine,Hunan Changsha,410208; *Shanghai Sun-Sail pharmaceutical Science &Technology Co,Ltd,Shanghai,201203) |
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| Abstract: | A facile synthesis of 4 - chloro - 3 - （4 - Bbenzyl） benzaldehyde was reported. The synthesis was performed by the acylation, reduction and hydroformylation of 2 - chloro -5 -bromo -benzoic acid. This procedure offered easy access to obtain key intermediates of Ertugliflozin in an accessible materials and facile conditions with good yields, even to reduce costs and improve production efficiency. |
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| Keywords: | SGLT - 2 inhibitor ertugliflozin 2 - chloro - 5 - bromo - benzoic acid |
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