| 水杨酸壳聚糖/卵磷脂纳米粒的制备 |
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| 引用本文： | 宋平. 水杨酸壳聚糖/卵磷脂纳米粒的制备[J]. 精细化工, 2012, 29(10): 972-975,984 |
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| 作者姓名： | 宋平 |
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| 作者单位： | 广东药学院医药化工学院 |
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| 摘 要： | 采用溶剂注入法制备水杨酸壳聚糖/卵磷脂纳米粒。考察了粒子结构、形貌特征及表面电位等性能,并探讨了制备工艺对药物包封率的影响。确定最佳制备工艺为:卵磷脂质量浓度20 g/L、卵磷脂与壳聚糖及水杨酸与载体的质量比分别为3∶1和1∶6、水相pH=4。所制备的水杨酸壳聚糖/卵磷脂固体纳米粒子为球形粒子、表面电位+18.7 mV、包封率及载药量可分别达到55%和8.07%。
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| 关 键 词： | 水杨酸 壳聚糖 卵磷脂 纳米粒 医药与日化原料 |
| 收稿时间： | 2012-05-24 |
| 修稿时间： | 2012-07-02 |
Preparation of salicylic acid-loaded lecithin/chitosan nanoparticles |
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| SONG Ping. Preparation of salicylic acid-loaded lecithin/chitosan nanoparticles[J]. Fine Chemicals, 2012, 29(10): 972-975,984 |
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| Authors: | SONG Ping |
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| Affiliation: | 1.College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China;2.Cosmetics Research and Development Department,The Mentholatum(China) Pharmaceuticals Company Limited,Zhongshan 528463,Guangdong,China;3.School of Chinese Materi Medica,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China;4.School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Zhongshan 528458,Guangdong,China) |
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| Abstract: | Salicylic acid-loaded lecithin/chitosan nanoparticles were prepared by solvent injection method.The structure,morphology as well as surface potential of the nanoparticles were investigated.The effects of preparation technology on drug entrapment efficiency were also studied by using the dialysis technique.The preparation process adapted to the formulation was as follows:the mass concentration of lecithin was 20 g/L,lecithin-chitosan and SA-carriers mass ratios were 3∶ 1 and 1∶ 6 respectively,and the pH of water phase reached 4.The Zeta potential of the optimized spherical nanoparticles was +18.7 mV with encapsulation efficiency and drug loading being 55% and 8.07% respectively. |
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| Keywords: | Salicylic Acid Lecithin Chitosan Nanoparticles |
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