| 抗真菌抗生素产生菌Fu发酵条件的优化 |
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| 引用本文： | 朱海东,周晓云,张朝晖. 抗真菌抗生素产生菌Fu发酵条件的优化[J]. 化学与生物工程, 2007, 24(2): 47-49 |
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| 作者姓名： | 朱海东 周晓云 张朝晖 |
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| 作者单位： | 杭州职业技术学院,浙江,杭州,310018;浙江工业大学,浙江,杭州,310032 |
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| 基金项目： | 浙江省杭州市科技局资助项目 |
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| 摘 要： | 运用单因素法和均匀设计法对链霉菌Fu培养基组成及发酵时间进行了优化,并用3 L发酵罐对菌种产抗生素的发酵动力学规律做了初步的探索.实验结果表明,菌种最佳摇瓶发酵培养基组成(%)为:可溶性淀粉7、酵母粉0.2、黄豆粉0.5、NaCl 0.15、MgSO40.03、 K2HPO4 0.04,发酵时间3 d.在罐培养至40 h左右菌体浓度达到最大,产抗生素水平在48 h左右达到最大.
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| 关 键 词： | 发酵 优化 均匀设计 |
| 文章编号： | 1672-5425(2007)02-0047-03 |
| 修稿时间： | 2006-11-03 |
Optimization of Fermentation Conditions for a Strain of Fu Producing Antifungal Antibiotics |
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| ZHU Hai-dong,ZHOU Xiao-yun,ZHANG Zhao-hui. Optimization of Fermentation Conditions for a Strain of Fu Producing Antifungal Antibiotics[J]. Chemistry & Bioengineering, 2007, 24(2): 47-49 |
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| Authors: | ZHU Hai-dong ZHOU Xiao-yun ZHANG Zhao-hui |
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| Affiliation: | 1. Hangzhou Vocational and Technical College, Hangzhou 310018 ,China ; 2. Zhejiang University of Technology, Hangzhou 310032, China |
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| Abstract: | The fermentation conditions for a strain of Fu producing antifungal antibiotics were optimized by single-factor experiments and uniform design experiments,and the fermentation dynamics was also studied in a 3 L bioreactor.The optimum fermentation medium in 250 mL flask was as follows(%): soluble starch 7,yeast powder 0.2,soybean meal 0.5,NaCl 0.15,MgSO4 0.03,K2HPO4 0.04,fermentation time 3 d.The fermentation dynamics in a 3 L bioreactor showed that the biomass reached the highest at the 40th hour of fermentation,and the antibiotics productivity was the highest at the 48th hour. |
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| Keywords: | fermentation optimization uniform design |
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