3-羟基-4-吡啶酮衍生物的合成及与Fe3+螯合性能

以甲基麦芽酚、对苯二胺、丙二酰氯为主要原料,微波辅助合成得到N,N'-二[对-(2-甲基-3-羟基-4-吡啶酮)苯基]丙二酰胺。采用IR、1HNMR、UV-vis、MS对产物结构进行了确证。采用分光光度法测定了该化合物对Fe3+的螯合性能,结果表明,在pH=7.40的Tris-水-乙醇缓冲溶液中,配体与Fe3+的配位比为1∶1,配合物表观稳定常数为lgK=7.76,证实该化合物对Fe3+具有潜在的螯合能力。

Synthesis and Chelating Property with Iron(III) Ion of 3-hydroxy-4-pyridinone Derivative

N,N'-bis-[4-(2-methyl-3-hydroxy-4-pyridinone)-phenyl]-malonamide was prepared by microwave- assisted synthesis with methyl maltol, p-phenylenediamine, malonyl dichloride as the main raw materials. The structure of the target product was characterized by means of IR, 1H NMR, UV-Vis and MS. And the chelating property with iron (III) ion has been measured by spectrophotometric determination. At pH = 7.40, the results show that the ligand coordination with Fe3+ is 1:1 under the Tris-water-ethanol buffer solution, the apparent stability constants of the complex is logK = 7.46, it was confirmed that the novel compound was potential chelating potency for iron (III) ion.